She makes her return in the 4th installment of the Resident Evil franchise and is powerless. She takes a few of her “friends” to the Umbrella Facility in Tokyo, only to find a few surprises. More of the ravaged undead, the iconic Majini from the hit video game, and an ally of hers since the cliffhanger ending of Extinction.
She will need as much help as she can get to stay alive, and save what’s left of the world.
In this installment the Alice clones (Jovovich) attempt to kill Albert Wesker (Roberts) at his base in Japan. All the clones are killed in an explosion as Wesker escapes in an aircraft. The original Alice ambushes him, but Wesker injects her with a serum that neutralizes the T-virus in her system, eliminating her superhuman powers and making her human again. Before he can kill her, the aircraft crashes and Alice emerges alone from the wreckage. Many months later, Alice follows a repeating emergency broadcast from a survivors’ safe haven known as “Arcadia”. After many fruitless months searching for Arcadia and finding no survivors along the way.
Alice begins to lose hope, believing herself to be the last surviving human on the planet. Stopping on an abandoned beach, Alice finds the helicopter taken by Claire and the others when they and Alice parted ways in the previous film. A crazed Claire, under the influence of an Umbrella Corporation device attached to her chest, attacks her. Alice removes the device, finding that it has damaged Claire’s memory. Claire slowly regains bits and pieces, remembering that Umbrella ambushed their group when they landed on the beach, attaching the devices to them, though she managed to escape.
Flying a two-person plane, they enter the ruins of Los Angeles and find a small group of survivors living in a maximum security prison, surrounded by zombies. They land the plane on the roof and learn that Arcadia is actually a cargo tanker traveling along the coast. Since the plane cannot take more than two, Alice and the survivors try to figure out a means to make it to Arcadia together. The survivors have been keeping watch on a prisoner, Chris (Miller), whom they found locked in a maximum security cell when they arrived.
Alice and survivors are out of time to find a means to reach Arcadia so they decide to free him and use his escape route. He recognizes Claire and reveals himself as her brother, though she does not remember him. Chris’ proposed methoda stored military vehicleis legitimate, but the vehicle is not operational and they are left with no other option but to use the zombies’ tunnel to escape into the sewers, which empties into the coast. The group fights off many zombiesAlice, Claire, and Chris emerging as the only survivorsand escape into the sewers.
They continue to Arcadia, finding the ship completely functional, but abandoned. Exploring its inner depths, they realize that it is a trap set by Umbrella to lure survivors to the ship to conduct experiments on them. They release the survivors, among them K-Mart, and Alice continues deeper, finding escape helicopters and a purging bomb. Deeper inward, she finds Wesker, who explains that he has been infected by the T-virus, mutating him and granting him super human abilities, but finds it difficult to control. By assimilating Alicethe only individual to bond successfully with the T-virushe will be able to gain full mastery of the T-virus. Chris, Claire, and Alice battle Wesker, but he escapes into a helicopter and activates the purging bomb to kill everyone aboard Arcadia. However, he finds that Alice hid the bomb aboard the helicopter and it is destroyed. During the purging bombs explosion, a parachute falling from the sky goes unnoticed by Alice, Claire, and Chris hinting that Wesker may still be alive.
Alice resolves to turn Arcadia into a real safe haven and broadcasts its message for any other survivors. As Claire, Chris, and Alice decide how to proceed with all the survivors, they see an approaching Umbrella assault fleet.